Spatially periodic calcium profiles around single channels
نویسنده
چکیده
The concept of calcium nanodomains established around the sites of calcium entry into the cell is fundamental for mechanistic consideration of key physiological responses. It stems from linear models of calcium diffusion from single channel into the cytoplasm, but is only valid for calcium increases smaller than the concentration of calcium-binding species. Recent experiments indicate much higher calcium levels in the vicinity of channel exit that should cause buffer saturation. I here derive explicit solutions of respective non-linear reaction-diffusion problem and found dichotomous solution for small fluxes the steady state calcium profiles have quasi-exponential form, whereas in the case of buffer saturation calcium distributions show spatial periodicity. These non-trivial and novel spatial calcium profiles are supported by Monte-Carlo simulations. Imaging of 1Dand radial distributions around single α-synuclein channels measured in cell-free conditions supports the theory. I suggest that periodic patterns may arise under different physiological conditions and play specific role in cell physiology.
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تاریخ انتشار 2016